Close background applications such as , RTSS (RivaTuner Statistics Server) , and Discord .

Ensure that your user account has full administrative permissions over the installation directory. Right-click re4.exe , go to > Compatibility , and check Run this program as an administrator . To help pinpoint your issue, please share a few details: What graphics card (GPU) are you currently using?

(ironic, but works for many) Same properties menu → Run this program in compatibility mode for Windows 7.