The C677T mutation is not just a silent change; it actively alters the MTHFR enzyme's structure, making it , meaning it is less stable and breaks down more easily at normal body temperatures. This thermolability directly correlates with a loss of enzymatic function. The severity depends on how many copies of the mutation an individual carries:
If METF stands for something else in your context (e.g., a company, a military program, a chemical process), please let me know and I will revise. metf ch4
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