The M-Audio Axiom Pro 49 is a MIDI device. This means that for basic MIDI functionality (playing notes into your DAW), you do not need a specific driver. Just plug it in, and macOS will recognize it.
Check the MIDI Studio: Go to Window > Show MIDI Studio. If the Axiom Pro 49 icon is bright, the Mac sees the device. maudio axiom pro 49 driver mac
The last official driver released by M-Audio was version 1.2.1.This driver was officially supported up to macOS 10.11 (El Capitan).For many users on macOS Sierra (10.12) through Mojave (10.14), this driver often still works, though you may need to disable System Integrity Protection (SIP) to install it—a move only recommended for advanced users. The M-Audio Axiom Pro 49 is a MIDI device
: The specialized "HyperControl" software—which allows for automatic fader and knob mapping in DAWs like Pro Tools, Logic, and Cubase—was primarily developed for older OS versions (up to roughly macOS 10.8) and is generally unsupported on modern 64-bit systems. Check the MIDI Studio: Go to Window > Show MIDI Studio
The setup experience depends heavily on whether you are running an older Intel-based Mac or a modern Apple Silicon machine.